Study of the cytokine genes SNPs association with the characteristics of the immunological status of children with recurrent respiratory infection

Background: Herpesvirus infections are one of the most common human that play a special role in children with recurrent respiratory infection cohort formation. The immunological status such is characterized by an imbalance all links immunity. aim study: To study RRI and to analyze association SNP -330T>G IL2 -1082G>A IL10 relative absolute values main subpopulations lymphocytes. Materials methods: In our study, we enrolled 76 between 10 17 years old who had acute at least 5 times year. Flow cytometry was used for lymphocyte analysis. Polymorphic variants were determined allele-specific PCR. Results: anti-NA EBV IgG anti-CMV positive AA genotype polymorphism average number B-lymphocytes 9.6%, which below normal (р=0.01). heterozygotes 12.4% subgroup GG genotype, 16.7% level NK cells 19.3% (р=0.04). Children lower (10.9%) Conclusion: Our studies revealed relationship immune indicators genotypes group. -1082AA associated decrease B-lymphocytes, as well increase cells. -1082GG tend NK-cells.